We also found that hyperglycemia and palmitate increased insulin resistance and induced UPR and PDIA4 signaling in murine C2C12 skeletal muscle cells in vitro, and that PDIA4 knockdown prevented the increase in insulin resistance and the expression of glucose transporter 4 (GLUT4) (Lee, et al. unpublished data). The gene discussed is PDIA4; the disease is Insulin resistance.