LGALS8 and systemic lupus erythematosus: Interestingly, neutralizing anti-Gal-8 autoantibodies that block Gal-8 interactions with glycans on β1-integrins and LFA-1 [37, 38], as well as Gal-8-induced apoptosis of T cells [29], are frequently generated in systemic lupus erythematosus (SLE), the prototypic autoimmune disease, and also in rheumatoid arthritis and probably other inflammatory disorders [39].