Here we study: 1) How the absence of Gal-8 function in a Gal-8 KO mice impinges upon lymphocyte subpopulations and EAE severity; 2) The effect of Gal-8 treatment on EAE of wild type mice; 3) The presence and clinical meaning of autoantibodies against Gal-8 in patients with MS. This evidence concerns the gene LGALS8 and myeloid sarcoma.