In a mouse model of autoimmune uveitis involving exacerbated Th1 and Th17 activities and Treg dysfunction, Sampson et al. [30] showed that Gal-8 treatment increased the differentiation of Tregs at sites of ongoing inflammation, such as draining lymph nodes and retina, but not systemically, as the spleen CD4+ T cell subpopulations remained unchanged. Here, CD4 is linked to autoimmune uveitis.