In the endothelial cells, angiogenesis marker, CD31, can be used to show the extent of tumor angiogenesis and imply a rapidly growing tumor.19 IHC analysis revealed that CD31 expression in the PBS, naïve exosome and LLC exosome treatment groups was higher than in the Plasmodium-infected exosome treatment groups (Figure 3c). This evidence concerns the gene PECAM1 and neoplasm.