VEGFA and neoplasm: The progression of the cell cycle from the G0 to S phase is believed to be mediated by some members of the miR-16 family, thereby inducing cell-cycle arrest and acting as potent tumor suppressors.39, 40, 41 Overexpression of either miR-15b or miR-16 repressed the expression of the target protein VEGF and the proliferation of early EPC (endothelial progenitor cells), while the opposite phenomenon was observed upon knockdown of these miRNAs.