Angiogenesis is vital for tumor growth, survival and progression.1, 2, 3 Vascular endothelial growth factor (VEGF) is one of the key angiogenic factors that drive vascular growth by attracting and activating cells from within the microenvironment of the tumor.4 Vascular endothelial cell surface contains VEGF binding sites which signal via three receptor tyrosine kinases (VEGFR1, 2 and 3) and are regulated at multiple levels. This evidence concerns the gene VEGFA and neoplasm.