KDR and neoplasm: The major mediators of tumor angiogenesis are VEGF-A and VEGF signals, which are regulated primarily through VEGFR2, which is expressed at increased levels by endothelial cells involved in angiogenesis.1, 20 The mice bearing a mutant VEGF gene only in vascular endothelial cells suggest that very low levels of autocrine-acting VEGF mediate endothelial cell survival and vascular homeostasis by signaling through intracellular VEGFR2.33 Our in vitro experiments showed that exosomes from the plasma of Py-infected mice suppressed VEGFR2 expression by endothelial cells.