Inhibition of SCD1 in cancer cells induces apoptosis by inducing ER stress or cytochrome c release.27, 45, 46 In other contexts, inhibition of SCD1 causes growth suppression by attenuating EGFR phosphorylation or palmitoylation of WNT3A.47, 48 ELOVL6 is overexpressed in several cancers including nonalcoholic steatohepatitis-related hepatocellular carcinoma,49, 50 squamous cell carcinoma37 and breast cancer,51 although the mechanism of its role in cancer cells is not yet clear. This evidence concerns the gene ELOVL6 and metabolic dysfunction-associated steatohepatitis.