Increased expression of lipogenic enzymes including ATP citrate lyase (ACLY), acetyl-CoA carboxylase A (ACACA) and fatty acid synthase (FASN) is correlated with poor prognosis in many types of cancer.14, 15, 16, 17, 18 In addition, numerous studies focused on the role for individual lipid metabolism enzymes in cancer. Here, ACLY is linked to cancer.