SHH and medulloblastoma: Our group reported that Rb regulates many enzymes implicated in the mevalonate and lipid synthesis pathways through E2Fs and SREBPs.12 In addition, it was shown that E2F1 participates in the control of fatty acid metabolism in Sonic hedgehog (Shh)-driven mice medulloblastoma.43 This work demonstrated that Sonic hedgehog signaling triggers de novo fatty acid synthesis through the Sonic hedgehog-Rb/E2F1-FASN axis while suppressing fatty acid oxidation.