ELOVL6 and hepatocellular carcinoma: Inhibition of SCD1 in cancer cells induces apoptosis by inducing ER stress or cytochrome c release.27, 45, 46 In other contexts, inhibition of SCD1 causes growth suppression by attenuating EGFR phosphorylation or palmitoylation of WNT3A.47, 48 ELOVL6 is overexpressed in several cancers including nonalcoholic steatohepatitis-related hepatocellular carcinoma,49, 50 squamous cell carcinoma37 and breast cancer,51 although the mechanism of its role in cancer cells is not yet clear.