PRKAA1 and neoplasm: As activated AMPK directly and indirectly inhibits mTOR8, 9, 10, 11, 12, 13, 14, 15, the LKB1-AMPK pathway controls mTOR activity, e.g., upon aberrant activation of Akt, which occurs in various types of tumours with loss of function of PTEN or PI3-Kinase gain of function mutations37.