Notably, several C-terminally truncated hLKB1 variants (due to nucleotide deletions or point mutations in STK11) with an intact kinase domain have been reported52 and OMIM to be associated with Peutz-Jeghers syndrome, which might be due to the function of the C-terminal region in PA-mediated activation of LKB1. Here, STK11 is linked to Peutz-Jeghers syndrome.