Moreover, we found that stomach adenocarcinoma (STAD) tends to have disproportionately higher number of NMD-elicit mutations and a mutator phenotype that selects for NMD-elicit mutations in LARP4B, EIF5B and PTEN. Although the potential relationship between LARP4B or EIF5B and cancer has been previously reported31, 32, 33, 34, the link between these genes and hypermutation was previously unrecognized. Here, EIF5B is linked to gastric adenocarcinoma.