Using a combined gene set consisting of both groups of genes, we found that promoter regions with BRCA1 mutation-associated R-loops are enriched with binding sites for breast cancer-related transcription factors, such as GATA3 and FOXA1 in LP cells and SMAD2/4 and STAT6 in ML cells (Fig. 3c). This evidence concerns the gene GATA3 and breast carcinoma.