It is also worth noting that tumour samples from triple-negative breast cancer patients, which contain the majority of BRCA1 mutation carriers, had significantly elevated COBRA1 mRNA as compared to normal breast epithelium from cancer-free individuals41 (2.55-fold, P=4.83 × 10−6 by two-tailed t-test). The gene discussed is NELFB; the disease is triple-negative breast carcinoma.