TP53 and breast carcinoma: The average age at breast cancer diagnosis for TP53 mutation carriers was significantly younger than for mutation-negative individuals (Table 4) (age at diagnosis 39 years vs. 48 years, p = 8 × 10−5), and TP53 mutation carriers were more likely to have bilateral breast cancer than mutation-negative individuals (36 vs. 13%, p = 0.05).