ZEB1 and breast cancer: P-cadherin is a proposed marker of hybrid E/M phenotype.35 Overexpression of the transcription factor ΔNp63α in breast cancer cells can drive collective cell migration and invasion and can induce a hybrid E/M phenotype in basal-like breast cancer (BLBC) cells by both activating miR-205 that inhibits ZEB1/2 and elevating the levels of SLUG, an activator of ZEB36–38 (Fig. 3a, b).