Recent characterization of metastatic breast cancer cells show that they retain some levels of epithelial adhesion genes such as E-cadherin10, 67 and that E-cadherin is essential for leveraging the advantages of the osteogenic niche and consequent colonization of bone by breast cancer cells, thereby providing potential mechanistic insights into the role of E-cadherin in IBC.68 The gene discussed is CDH1; the disease is breast cancer.