CDH1 and lung carcinoma: These results are reminiscent of implications of E-cadherin in collective chemotaxis in vivo,76 and that knockdown of GRHL2 or OVOL2—top activators of E-cadherin77—disrupt collective finger-like motion in vitro in lung cancer cells.29 Another potential mechanism through which E-cadherin can drive aggressive behavior is the survival of clusters in the bloodstream by ‘synoikis’, i.e., activation of survival signals through junctional adhesions between neighboring cells.78