PORCN and cancer: The compensatory WNT pathway observed in our study is well known for its role in tissue development and cancer metastases.20 Of interest, both in silico bioinformatic prediction (based on a large literature database) as well as next generation RNA-sequencing of a TNBC cell line treated with buparlisib saw induction of numerous Wnt pathway molecules including the FZDs, WNT ligands, LRP4/6, PTK7, and porcupine (PORCN).