Thus, mice containing an inducible cassette able to express all four Yamanaka reprogramming factors (Oct4, Sox2, KLF4 and cMyc) can induce teratomas in many tissues, but the frequency at which this occurs is significantly increased by both p53 tumor suppressor inactivation and exposure to a senescence-like environment.140 It is tempting to speculate that cell reprogramming enabled by both relevant mutations and exposure to senescent cells that accumulate with age provides one explanation for the link between cancer and aging. Here, TP53 is linked to cancer.