SCO2 and cancer: We previously showed that, in human cell lines and a mouse model, the S47 variant exhibits a modest decrease in apoptosis in response to most genotoxic stresses compared with wild-type p53, but exhibits a significant defect in cell death induced by cisplatin.8 The variant shows impaired ability to transactivate a subset of p53 target genes, including two involved in metabolism: Gls2 (glutaminase 2) and Sco2. We showed that mice expressing S47 in homozygous or heterozygous form are susceptible to spontaneous cancers of diverse histological types.