Previous studies have shown that the cystic fibrosis transmembrane conductance regulator (CFTR) is an important receptor for Typhi42, 43 and has also been found to internalize within colonic crypt epithelial cells in a mouse model of Typhimurium-induced enteritis.44 However, immunohistochemical profiling of our uninfected 3-D epithelial and co-culture models revealed no differences in the localization or expression of CFTR that would explain these differences in adherence (data not shown). Here, CFTR is linked to enteritis.