RAC1 and Alzheimer disease: After 4 days of induction, regardless of the conditions, we observed significant increases by strontium in RhoA-GTP and Rac1-GTP activities (e.g., for RhoA: +52 %, p < 0.01 at D6 in AD and +75 % at D6 in OB, p < 0.001; for Rac 1: +43 %, p < 0.01 at D6 in AD and +34 %, p < 0.05 at D6 in OB).