Increased levels of neurogranin, as well as SNAP25 in CSF of early prodromal AD patients have been reported11,29 and neurogranin levels were also correlated with cognitive impairment in prodromal AD,10 underlining the importance of neurogranin as a potential prognostic biomarker for neurodegenerative diseases. The gene discussed is SNAP25; the disease is Cognitive impairment.