NRGN and Alzheimer disease: We have recently reported alterations in strategic synaptic protein levels involved in key steps of the synaptic machinery in post-mortem brain studies in PD and AD.18–21 Neuron specific neurogranin was chosen based on its involvement in the regulation of synaptic transmission through its binding to calmodulin at low levels of calcium.22 SNAP25 is known to provide the driving force for vesicle fusion and docking,23 while the protein Rab3A reflects the recycling pool of synaptic vesicles.24