ANPEP and synucleinopathy: To examine this, we recently demonstrated that intranasal administration of APN ameliorated neuropathological features, such as protein aggregation and impaired motor activity, in a transgenic mouse model of α-synucleinopathies.57 Subsequently, osmotin, the plant homolog of APN, was also shown to attenuate Aβ42-induced neurotoxicity and tau hyperphosphorylation in hippocampus of wild mice.90