Gene expression profiling37 of 11 BRAFV600E-CRC cell lines (including 3/4 above) revealed that transcripts encoding MET and FGFR4 are expressed at levels equivalent to EGFR in these cells, as are IGFR2 and ERBB3, regulators of PI3K/Akt signaling (Fig. S2). This evidence concerns the gene FGFR4 and colorectal carcinoma.