Inhibition of guanine nucleotide-binding protein subunit alpha-11, 14, and 15 (GNA-11,14,15), along with GNAQ, inhibits 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, 2, 3, and 4, thus reducing cardiac hypertrophy through EGFR blockade. The gene discussed is GNA11; the disease is cardiac hypertrophy.