Of the evaluated breast cancer cell lines with mutations in BRCA1 (MDA-MB-436 and HCC-1937) or BRCA2 (HCC-1569, BT-20, BT-474, MDA-MB-361), only one (HCC-1569) was found to respond to BMN-673. The gene discussed is BRCA2; the disease is hepatocellular carcinoma.