Genes with genetic polymorphisms implicated with increased susceptibility to tuberculosis reported in literature12 and from the Online Mendelian Inheritance in Man database39 were enlisted, and 30 of these genes were seen to occur in the common core. These include STAT1, CXCL10, TLR2, IRF1, RBBP8, VDR, IL10, IFNG, IFNGR1, AKT1, CCR2, CCR5, CISH, CYBB, IKBKG, IL12A, IL12B, IL12RB1, IL12RB2, IL1B, IRF8, MMP9, MYD88, NGFR, NR1H2, PAK2, TBK1, TBX21, TNFRSF1A, and TOLLIP, and are highlighted in Fig. 4. The gene discussed is IL12RB1; the disease is tuberculosis.