Significant genes that mediate such downregulation include the chemokines CCL7, CCL20, CCL25, RPS3, MYC, CYP2E1, CD19, ADCY8, FYN, IRF3, WNT1 and WNT3. The genes PAK6 and CRIP2, which are present in this repressed network are also seen to emerge in the active response networks post anti-tubercular treatment, further strengthening the finding that these are indeed infection-induced downregulations which respond to treatment. The gene discussed is ADCY8; the disease is infection.