Numerous studies have been done on these ncRNA loci, reporting the potent phenotypes induced by their genetic perturbations and by overexpression/deletion of these loci-associated miRNAs, thus placing these genetic regions at the center of numerous cellular and developmental pathways.41–43MIR17HG and MIR100HG clusters and their paralogs have been placed at the nexus of opposing activities during malignancy development: oncogenic41, 44 and tumor-suppressive,42, 45, 46 respectively. This evidence concerns the gene MIR100HG and neoplasm.