EGFR and Alzheimer disease: Similar observations were made by observing the microbiome of affected and unaffected skin of patients with AD before and after emollient treatment.51 Using a mouse model, Kobayashi et al. proved that impaired epidermal growth factor receptor (EGFR) signaling can lead to dysbiosis, which in itself leads to eczematous inflammation, similar to that of human AD.52 Such an understanding of the role of the skin microbiome in AD supports initiatives to realize the power in harnessing, stabilizing, and directing the resident skin microbiota to establish a healthy state.