CytomX has demonstrated the ability of a Probody T cell-engaging bispecific (Pb-TCB) targeting CD3 and epidermal growth factor receptor (EGFR), to provide equivalent anti-tumor activity in NSG (NOD scid gamma) mice to its corresponding unmasked antibody bispecific, while increasing the maximum tolerated dose and exposure by >30-fold and 300-fold, respectively, in cynomolgus monkeys. The gene discussed is EGFR; the disease is neoplasm.