However, a significant decrease in the median WE IgE/IgG4 ratio (indicative of evolving tolerance to egg) was observed with time in both BE intervention (15.63 (3.51–35.00) to 2.91 (0.88–9.21), p = 0.02) and control groups (17.50 (3.86–50.18) to 8.28 (0.74–14.13), p = 0.04) (Fig. 4). Here, IGHE is linked to Barrett esophagus.