TNFRSF4 and hepatocellular carcinoma: In this regard, we have previously demonstrated that OX40+ Treg cells, expanded in cirrhotic liver, hepatocellular carcinoma, and CRC, exhibit a phenotype (Helioshi, CD39hi) compatible with a strong suppressive activity, a high proliferative potential and a stable regulatory program, suggesting that CRC may take advantage from creating a favorable milieu for their accumulation (29).