CLRs are important for the immune response against parasites, and in some studies example has been observed that, for example, CLRs are related with cerebral malaria in mice infected by Plasmodium berghei, and CARD9 is upregulated, but CARD9−/− mice were not protected from infection, suggesting that the CARD9 receptor influences infectivity by the plasmodium but in its absence (as demonstrated in knockout animals) does not prevent the disease from occurring (McGuinness et al., 2003). Here, CARD9 is linked to cerebral malaria.