SIGLEC1 and parasitic infectious disease: Another study conducted with P. chabaudi demonstrated that the mannose receptor C type 2 (MRC2) increased with parasitemia, but toll-like receptors and sialoadhesin decreased in contrast to other MRCs (1 and 2), and that decreased with parasitemia in P. yoelii, suggesting the importance of lectin-receptors in the development of mounting of the immune response (Rosanas-Urgell et al., 2012).