In this previous study, we proposed a new possible mechanism by which P6 negatively regulates COX-1 expression thereby NF-kB mediated signal-pathway modulation, suggesting the necessity of further studies to validate the efficacy of P6 as well as its analogs in the treatment of neuroinflammatory-based neurodegenerative disease (14). The gene discussed is NFKB1; the disease is neurodegenerative disease.