TRPA1 and TRPV1 have also been involved in the development of migraine, which can be activated by a number of TRPA1 agonists (Benemei et al., 2014) and might be attenuated by repeated desensitizing administration of capsaicin to the nasal mucosa (Fusco et al., 2003). The gene discussed is TRPV1; the disease is migraine disorder.