Although OX1R antagonists may not alleviate mild anxiety or all anxiety associated symptoms they do appear to be effective in rapidly reducing panic and fear associated responses in most stress paradigms, especially as they become more severe, without sedation side effects that would be associated with OX2R antagonists or fast acting panicolytic benzodiazepines (Nutt et al., 2002; Baldwin et al., 2005; Bandelow et al., 2008; Cloos and Ferreira, 2009). This evidence concerns the gene HCRTR1 and Anxiety.