Additionally, in rats a selective OX1R antagonist blocks cellular responses in panic and anxiety brain circuits (e.g., amygdala and dorsal periaqueductal gray and sympathetic nuclei) post-administration of a panicogenic drug (Johnson et al., 2012c), and in humans recent imaging data indicate that a selective OX1R antagonist produced a region-dependent inhibition of yohimbine-induced activation in fronto-hippocampal regions as well as in several key components of the extended amygdala (Gozzi et al., 2013). Here, HCRTR1 is linked to Anxiety.