SOD1 and systemic lupus erythematosus: Thus, enzymatic antioxidant scavengers superoxide dismutase 1, thioredoxin, and peroxiredoxins 1 and 6 were significantly increased in SLE-MPs while others such as peroxiredoxins 3 (mitochondrial) and 4 (endoplasmatic reticulum), glutathione peroxidase 3 (GPX3), a plasma protein, and manganese superoxide dismutase (mitochondrial) were significantly decreased.