As for proteins maintaining phospholipid bilayer asymmetry, cell cycle control protein 50A (TMEM30A) and anoctamin-6 (TMEM16F), an ATP-dependent flippase and a scramblase, respectively, were both significantly decreased in SLE-MPs (Additional file 1: Fig. S8) and not altered in SSc-MP. Here, ANO6 is linked to systemic lupus erythematosus.