Mediators and effectors of apoptosis: Caspase-3, BH3-interacting domain death agonist (BID), cytochrome c, calpains, and PDCD6 interacting protein (PDCD6IP, Alix) were all significantly increased in SLE-MPs (Fig. 5b). This evidence concerns the gene PDCD6IP and systemic lupus erythematosus.