Changes in the coagulation system have also been detected during vasovagal reflex activation: a study performed in subjects with von Willebrand disease has demonstrated increased antigen concentration of von Willebrand factor (VWF:Ag), VWF-Ristocetin-cofactor, and factor VIII activity (FVIII:C) after fainting prompted by fear of venepuncture [9]. The gene discussed is VWF; the disease is platelet-type von Willebrand disease.