In melanoma and acute inflammatory liver injury, RIPK3-activated PGAM5 regulates the dephosphorylation of DRP1 as well as NFAT to promote type 1 natural killer T cell activation and proinflammatory cytokine production, suggesting that the RIPK3-PGAM5-DRP1 signaling axis may mediate crosstalk between mitochondrial function and host immunity in these disease states (Kang et al., 2015). This evidence concerns the gene PGAM5 and melanoma.