Our previous attempts to identify genetic associations between POAG and polymorphisms in genes including caveolin (CAV1/CAV2) [10], atonal homolog 7 (ATOH7) [11], cyclin-dependent kinase inhibitor 2B (CDKN2B) [12], and transmembrane and coiled-coil domain 1(TMCO1) [13] did not yield any positive results indicating that the genetic cause for POAG in patients of Saudi origin may be different than those from European descent. Here, CDKN2B is linked to open-angle glaucoma.