Some of these are included in complex clinical syndromes such as branchio-oto-renal syndrome (EYA1, SIX1), renal-coloboma syndrome (PAX2), renal cysts and diabetes syndrome (TCF2/HNF1B) and Townes–Brocks syndrome (SALL1). This evidence concerns the gene EYA1 and branchio-oto-renal syndrome.