CDKN2A and melanoma: As noted previously, aggregates of apparently nonmalignant, nonproliferative, p16INK4a-expressing, melanocytic nevus-like cells, in the absence of any concurrent or subsequent melanoma, have also been reported in the skin-draining lymph nodes of humans (Mihic-Probst et al., 2003, Patterson, 2004) (albeit not as frequently or markedly as observed in the Tyr-NrasQ61K mouse model).