BRAF and melanoma: In the coBRIM study, the combination of cobimetinib, a MEK inhibitor, with vemurafenib, a BRAF inhibitor, significantly improved progression-free survival (PFS) [6] and overall survival (OS) [7] compared with placebo and vemurafenib (hereafter referred to as vemurafenib) in advanced BRAFV600-mutated melanoma.