In 2015, Mott et al. [39] found that a small amount of CD8α + DCs could be detected in Batf3−/− mice infected with HSV-1, and HSV-1 latency situation in Batf3−/− mice was not different from wild-type mice, while latent infection was attenuated in BXH 2 mice (Irf8 mutant). The gene discussed is CD8A; the disease is disease arising from reactivation of latent virus.