In this study, we showed that the absence of Batf3 alleviated liver damage in Batf3−/− mice infected with S. japonicum. We found alleviated liver granulomatous inflammation in Batf3−/− mice with schistosomiasis japonica could not be attributed to the difference in schistosome egg or worm burden. This evidence concerns the gene BATF3 and Schistosomiasis japonica.