Autoantibodies against MOG are implicated in pediatric MS [11] and acute disseminated encephalomyelitis (ADEM) [12] as well as in a subset of water channel aquaporin-4 (AQP4)-IgG seronegative neuromyelitis optica spectrum disorder (NMOSD) [13–15]. Here, AQP4 is linked to acute disseminated encephalomyelitis.