TLR3 and infection: The associations of SNPs in TLR3 and MIF with the neuroinvasive TBEV infection, of TLR3 with the prolonged intrathecal inflammation, and of MIF rs755622 with the clinical presentation are consistent with the TLR3- and MIF-dependent activity increasing the risk of the progression to a clinically overt CNS involvement while in the same time decreasing its severity.