IGF1 and Hearing impairment: In participants aged 60 and over, there was evidence of a ‘J’-shape, with higher odds of hearing impairment observed at higher levels of IGF-1.To our knowledge, this is the first study to assess the association between IGF-1 and hearing impairment in a population-based study, despite the use of this hormone as an alternative treatment for sudden hearing loss in clinical trials37.