Out of 46 genes tested, only the expression of 4 genes was significantly modulated in TR-T2D patients vs. UT-T2D: specifically, growth arrest and DNA damage (GADD45) and histone H2A (H2AFX) genes were up-regulated, while uracil-DNA glycosylase (UNG) and Oxidation Resistance 1 (OXR1) were down-regulated. This evidence concerns the gene H2AX and type 2 diabetes mellitus.