H2AX and type 2 diabetes mellitus: With respect to significantly regulated genes, out of the 46 genes tested, trained T2D showed a decreased expression of both Uracil-DNA Glycosylase (UNG) (fold change 0.38, P = 0.04), and Oxidation Resistance 1 (OXR1) (fold change 0.35, P = 0.006), as well as an increased expression of H2A Histone Family Member X (H2AFX) (fold change 1.93, P = 0.04) and Growth Arrest And DNA Damage 45 (GADD45) (fold change 3.40, P = 0.003) (Table 2).