Finally, AngII induced IL-10 production by B cells was significantly attenuated by Agtr1a deficiency, and transfer of Apoe−/−/Baffr−/− mice with Agtr1a−/− B cells in the presence of AngII led to increased atherosclerosis compared with the transfer of Agtr1a+/+ B cells. Here, APOE is linked to atherosclerosis.