IL18 and adult-onset Still disease: As shown in Fig. 4d, significantly higher levels of miR-134 and IL-18 were observed in the plasma of active AOSD patients (mean, 6.4-fold, and 3844.0 pg/ml, respectively) compared to inactive AOSD patients (mean, 2.4-fold, P < 0.01 and 1863.6 pg/ml, P < 0.05, respectively) and controls (mean, 0.3-fold, P < 0.001 and 112.0 pg/ml, P < 0.001, respectively).