The significantly higher IL-18 levels in miR-134 over-expressing cells when compared with control cells, without significant difference in the levels of the other cytokines (IL-1β, IL-6, IL-17A, or TNF-α), suggests a close link of miR-134 expression with levels of IL-18, a key cytokine in AOSD pathogenesis16, 21, 38–42. This evidence concerns the gene IL1B and adult-onset Still disease.