BIRC5 and colorectal carcinoma: Moreover, in many solid tumors, especially in CRC, constitutive activation of NF-κB has been observed14, where NF-κB acts as a transcription factor that contributes to the progression of CRC by regulating the expression of diverse target genes involved not only in inflammation but also in apoptosis (XIAP, Survivin, Bcl-2, Bcl-xl, and others).