CHUK and colorectal cancer: The expression of NF-κB-dependent anti-apoptotic genes (XIAP, Bcl-xl, and Bcl-2) was also shown to be downregulated, suggesting that miR-15b-5p negatively regulates NF-κB1 and IKK-α, resulting in the suppression of NF-κB-dependent survival proteins in colorectal cancer.