A timely and detailed review and a meta-analysis by Mostaid et al. 16,22 demonstrated that, despite the fact that whole-genome association studies did not confirm a link between NRG1/ErbB genes and schizophrenia, there is substantial evidence from other types of preclinical and clinical studies that NRG1 may be relevant in the pathophysiology of schizophrenia by regulating not only synapse formation but the balance between excitatory (glutamatergic) and inhibitory (GABA-ergic) neurotransmission. This evidence concerns the gene EGFR and schizophrenia.