To establish its utility for generating cells for disease modeling, we used the new single‐vector system to convert dermal fibroblasts from healthy adults as well as individuals with sporadic PD, familial PD (LRRK2 c.6055G>A mutation), HD (41 CAG repeats), and familial AD (APP KM670/671NL mutation) (Appendix Table S2). Here, LRRK2 is linked to Huntington disease.