Treatment with combined CTLA4 and PD1 Abs in dKO mice virtually abrogated tumor growth and increased infiltrates of CD8 T cells as well as its effector functions compared with dKO mice treated with control mAbs (p < 0.004) (Figs. 3A, 4A, 4C, Supplemental Fig. 3E, 3F). Here, CTLA4 is linked to neoplasm.