To tease apart the effect further, a cohort of 6- to 8-wk-old female C57BL/6 mice was inoculated with tumor, and 5 d later, after the tumors had become established, combinations of blocking (CTLA4, PD1, OX40L, CD30L) or control mAbs were administered twice weekly until tumors reached the tumor size limit (12 mm in diameter) or day 42, at which point the remaining animals were sacrificed and analyzed. This evidence concerns the gene TNFSF8 and neoplasm.