MMP1 and tuberculosis: Increased DQ collagen fluorescence, which corresponds to areas of collagen breakdown, was markedly increased with M. tuberculosis infection, compared with uninfected controls, but when integrin β3 was inhibited by 20 μg/ml anti-integrin β3 Abs, collagen breakdown decreased, as well as the number of cells adherent to the collagen-coated slide, which further implicates integrin αVβ3 on regulation of MMP-1 activity in TB (Fig. 7A).