MEIS1 and restless legs syndrome: MEIS1 cooperates with other transcription factors to perturb myeloid differentiation in leukemogenesis (Nakamura et al., 1996) and, in genetic association studies, it has been linked with restless legs syndrome (RLS) (Winkelmann et al., 2007, 2011), periodic leg movements during sleep (Moore et al., 2014; Stefansson et al., 2007), symptoms of insomnia (Lane et al., 2016), PR interval (Butler et al., 2012) and waist-to-hip ratio (Shungin et al., 2015).