In Ifnar1 KO cultures, 4% (n = 3) and 12% (n = 3) of DAPI +ve nuclei were pyknotic at 24 hpi and 72 hpi following infection with ZIKV with an MOI of 0.3 and 3.0, respectively, compared to 3% (n = 3) in mock-infected controls. The gene discussed is IFNAR1; the disease is infection.